Programs & Initiatives
According to the national Centers for Disease Control and Prevention (CDC), more than 1.2 million people in the United States are living with human immunodeficiency virus (HIV), which can progress to acquired immunodeficiency syndrome (AIDS). The National Institute of Allergy and Infectious Disease (NIAID) Division of Clinical Research (DCR) is funding an HIV Replication Study to better understand how the virus reproduces in viral reservoirs, or tissues that carry the virus, in patients whose disease is suppressed. This information could be used to improve HIV therapies.
Leidos Biomedical Research, Inc., the operations and technical support contractor for the Frederick national Laboratory for Cancer Research, is conducting the study. Leidos Biomed subcontracted NDRI to pilot an HIV tissue procurement program, beginning in 2017. NDRI will draw on its nationwide network of tissue source sites (TSSs) to collect high-quality biospecimens. The goal of the program is to collect a variety of tissue types from 10 deceased donors with HIV and to conduct DNA and RNA analysis of the viral strains that persist in cellular compartments within different tissue types. NDRI is working with multiple TSSs to identify patients who are eligible for this project and who die from reasons other than their HIV infection.