NDRI: Publications

• 2018 • Biopharmaceutics Drug Disposition

Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.

Quach HP, Noh K, Hoi SY, Bruinsma A, Groothuis GMM, Li AP, Chow ECY, Pang KS

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• 2018 • Molecular Therapy

Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression.

Willoughby JLS, Chan A, Sehgal A, Butler JS, Nair JK, Racie T, Shulga-Morskaya S, Nguyen T, Qian K, Yucius K, Charisse K, van Berkel TJC, Manoharan M, Rajeev KG, Maier MA, Jadhav V, Zimmermann TS

Full Article

• 2018 • J Clin Invest 2018 Oct 1;128(10): 4501-4509

No recovery of replication-competent HIV-1 from human liver macrophages

Kandathil AJ, Sugawara S, Goyal A, Durand CM, Quinn J, Sachithanandham J, Cameron AM, Bailey JR, Perelson AS, Balagopal A.

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• 2018 • Biopharm Drug Dispos. 2018 Mar;39(3)

Inhibitory effects of sulfonylureas and non-steroidal anti-inflammatory drugs on in vitro metabolism of canagliflozin in human liver microsomes

Algeelani S, Alkhelb D, Greenblatt DJ

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• 2018 • Xenobiotica. 2018 Aug;48(8):764-769

In vitro inhibition of human UGT isoforms by ritonavir and cobicistat

Algeelani S, Alam N, Hossain MA, Mikus G, Greenblatt DJ

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• 2018 • Biochem Pharmacol. 2018 May;151:69-78

Identification of enzymes responsible for dantrolene metabolism in the human liver: A clue to uncover the cause of liver injury

Amano T, Fukami T, Ogiso T, Hirose D, Jones JP, Taniguchi T, Nakajima M

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• 2018 • Biochem Pharmacol. 2018 Sep;155:242-251

In vitro approach to elucidate the relevance of carboxylesterase 2 and N-acetyltransferase 2 to flupirtine-induced liver injury

Konishi K, Fukami T, Ogiso T, Nakajima M

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• 2018 • J Vet Pharmacol Ther. 2018 Dec;41(6):815-824

Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes

Perez Jimenez TE, Mealey KL, Schnider D, Grubb TL, Greene SA, Court MH

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• 2018 • Drug Metab Pharmacokinet. 2018 Aug;33(4):203-210

miR-141-3p commonly regulates human UGT1A isoforms via different mechanisms

Tatsumi N, Tokumitsu S, Nakano M, Fukami T, Nakajima M

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