This initiative aims to help researchers develop more successful treatments for childhood diseases
The National Disease Research Interchange (NDRI) is proud to announce that the Developmental Genotype Tissue Expression (dGTEx) project, a groundbreaking study of childhood cell development, has reached an important milestone with the release of its first data. dGTEx V1 contains 379 samples (342 RNA-seq and 37 WGS) from 40 subjects and the open access data is now available on the Open Access Download Page.
The dGTEx project is an NIH initiative to establish a resource of pediatric human tissues and comprehensive gene expression data. The project aims to collect tissues and build gene expression profiles from at least 120 postmortem pediatric donors to better understand developmental specific genetic effects on complex traits and diseases.
“We are so excited to release the first dGTEx data,” said Patrick Van Hoose, PhD, NDRI’s Director of NIH Initiatives. “The dGTEx project will revolutionize the treatment of childhood diseases and we are happy to get this information out to researchers.”
dGTEx is an extension of the GTEx program, which the NIH launched in 2010 in response to a gap in the availability of high-quality human tissue samples and associated gene expression information. NDRI works with our Biospecimen Procurement Center Partners at Children’s Hospital of Philadelphia, the University of Maryland, and Johns Hopkins All Children’s Hospital, as well as our Laboratory Data Analysis Collection Center Partners at the Broad Institute and Yale School of Medicine. dGTEx is funded by the National Human Genome Research Institute (NHGRI), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Mental Health (NIMH), and the National Institute of Neurological Disorders and Stroke (NINDS).