Somatic Mosaicism Across Human Tissues (SMaHT) Program

The Somatic Mosaicism Across Human Tissues (SMaHT) Network is an NIH Common Fund initiative that will provide the first comprehensive public resource for analyzing genetic variation due to somatic mosaicism in human tissues from all developmental layers in the human body.

NDRI, in collaboration with the University of Maryland School of Medicine and Johns Hopkins All Children’s Hospital, were awarded a research grant by the NIH to serve as the Tissue Procurement Center (TPC) for the SMaHT Network. NDRI will work with a network of organ procurement organizations to collect, store, and distribute multiple healthy tissues across body systems from a diverse pool of at least 150 organ and tissue donors.

NDRI’s Role in the SMaHT Process

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Our Tissue Procurement Center (TPC) partners for SMaHT:

• University of Maryland
• Johns Hopkins All Children’s Hospital

Organizational Center (OC) for SMaHT:

• Washington University

Data Analysis Center (DAC):

• Harvard University

Genome Characterization Centers (GCC):

• Broad Institute
• University of Washington and Seattle Children’s Research Institute
• New York Genome Center
• Baylor College of Medicine
• Washington University

Tool and Technology Development (TTD) Centers:

• Mayo Clinic Rochester
• Dana-Farber Cancer Institute
• Broad Institute
• Boston Children’s Hospital
• New York University School of Medicine
• University of Massachusetts Medical School Worcester
• Case Western Reserve University
• Weill Medical College of Cornell University
• University of Utah
• University of Michigan Ann Arbor
• Baylor College of Medicine
• Stanford University

SMaHT Funding Partners:

• Office of the Director (OD), Office of Strategic Coordination

Somatic Mosaicism Across Human Tissues (SMaHT) Program

The Somatic Mosaicism Across Human Tissues (SMaHT) Network is an NIH Common Fund initiative that will provide the first comprehensive public resource for analyzing genetic variation due to somatic mosaicism in human tissues from all developmental layers in the human body.

NDRI, in collaboration with the University of Maryland School of Medicine and Johns Hopkins All Children’s Hospital, were awarded a research grant by the NIH to serve as the Tissue Procurement Center (TPC) for the SMaHT Network. NDRI will work with a network of organ procurement organizations to collect, store, and distribute multiple healthy tissues across body systems from a diverse pool of at least 150 organ and tissue donors.

NDRI’s Role in the SMaHT Process

Click to enlarge

Our Tissue Procurement Center (TPC) partners for SMaHT:

• University of Maryland
• Johns Hopkins All Children’s Hospital

Organizational Center (OC) for SMaHT:

• Washington University

Data Analysis Center (DAC):

• Harvard University

Genome Characterization Centers (GCC):

• Broad Institute
• University of Washington and Seattle Children’s Research Institute
• New York Genome Center
• Baylor College of Medicine
• Washington University

Tool and Technology Development (TTD) Centers:

• Mayo Clinic Rochester
• Dana-Farber Cancer Institute
• Broad Institute
• Boston Children’s Hospital
• New York University School of Medicine
• University of Massachusetts Medical School Worcester
• Case Western Reserve University
• Weill Medical College of Cornell University
• University of Utah
• University of Michigan Ann Arbor
• Baylor College of Medicine
• Stanford University

SMaHT Funding Partners:

• Office of the Director (OD), Office of Strategic Coordination