Administrative supplement grants expanded the impact of HTORR. To build and implement programs to support more complex, disease-specific initiatives for the NIH, HTORR frequently utilizes the administrative supplement pathway. The aims of supplement applications fall well within the scope of the parent award aims but are beyond the current budgeted means that support HTORR’s general infrastructure and services.
HTORR has been awarded 16 administrative supplement grants over the last 5 years. Fourteen administrative supplement grants focused on supporting several high priority areas of research for the NIH: HIV (n=4), Alzheimer’s Disease (n=5), autism spectrum disorders (n=4), and Hearing and Balance disorders (n=1). HTORR was also awarded two additional administrative grants: 1) Diversity Administrative Supplement to support the advancement of an individual with a health disparity and 2) Alterations and Renovations (A&R) Administrative Supplement to enhance and expand the cold storage capabilities of HTORR. HTORR was also awarded one additional equipment grant: R24 Modern Equipment for Shared-use Biomedical Research Facilities: Advancing Research-Related Operations.
List of active HTORR supplements and related grants:
The primary objective of this grant is to maintain and expand the collection and disbursement of tissues vital for research into hearing and balance disorders. Learn more about the program here.
Recently funded by National Institute of Allergy and Infectious Diseases (NIAID), the goal of this administrative supplement is to continue providing samples to support a large-scale biospecimen collection program (~120 aliquots per donor) from HIV+ donors, using multiple preservation methods to support the advancement of sequencing studies in Dr. H. Clifford Lane’s laboratory at NIAID.
Our recently completed supplemental awards:
The HTORR-ADBR Program administrative supplemental grant was funded by the National Institute on Aging (NIA) to support Alzheimer’s Disease and AD-related dementia (AD/ADRD). The goal of the ADBR was to serve as a comprehensive resource that provides biospecimens from all body systems, including whole brains or hemispheres, from AD and normal donors to address a diverse range of investigator-driven experimental needs for the AD research community.
The HTORR-ASD Brain recovery Program was supported by the National Institutes of Mental Health NIMH) to advance ASD research. The major goals of this program were to support NIH’s NeuroBioBank program by developing and maintaining a recovery network to screen and collect biospecimens from ASD and normal donors for the NeuroBioBank at University of Maryland. Doing so provided investigators with expanded access to valuable donated human brain biospecimens to support the advancement of their ASD studies.
The Diversity Supplements Program was established by the NIH to provide support for individuals from diverse backgrounds looking to develop their careers in research. One component of this HTORR administrative supplement award was a research project that evaluated the integrity and viability of long term stored human tissue samples utilizing NDRI’s collection of Lymphangioleiomyomatosis (LAM) samples, as well as to evaluating LAM investigator interest in utilizing long term stored human tissues samples.
NDRI was awarded a research resource grant from the National Institute on Aging (NIA) to support the development of the Ocular Tissue Resource for Alzheimer’s Disease (OTR-AD). The overall objective of the OTR-AD was to provide well-annotated ocular and other supporting tissues/fluids from defined cohorts of healthy and AD donors to meet the emerging experimental needs of AD investigators.
The Alterations & Renovations (A&R) Program was funded by Office of Research Infrastructure Programs/ Division of Comparative Medicine (ORIP/DCM), provides the opportunity to improve and expand the cold storage infrastructure of HTORR by obtaining new equipment for the biorepository and Tissue Source Sites (TSS).