HTORR Administrative Supplemental Grant Awards
Administrative supplement grants expanded the impact of HTORR. To build and implement programs to support more complex, disease-specific initiatives for the NIH, HTORR frequently utilizes the administrative supplement pathway. The aims of supplement applications fall well within the scope of the parent award aims but are beyond the current budgeted means that support HTORR’s general infrastructure and services.
HTORR has been awarded fourteen administrative supplement grants over the last five years. Twelve administrative supplement grants focused on supporting three high priority areas of research for the NIH: HIV (n=3), Alzheimer’s Disease (n=5), and autism spectrum disorders (n=4) projects. HTORR was also awarded two additional administrative supplement grants: 1) Diversity Administrative Supplement to support the advancement of diversity in the scientific workforce and the career training of an individual with a health disability and 2) Alterations and Renovations (A&R) Administrative Supplement to enhance and expand the cold storage capabilities of HTORR.
List of HTORR supplemental grant submissions currently under review:
R24 New equipment grant submission:
The primary objective of our R24 Equipment Program grant submission is to obtain new equipment to modernize our cold storage mapping and temperature monitoring infrastructure and capabilities for our CAP-accredited biorepository.
Brain and Other Tissues for AD/ADRD Research Resource (BOTARR)
Research into Alzheimer’s disease and related dementias (AD/ADRD) is currently slowed by the absence of accurate animal models, emphasizing the need for primary disease and control human tissue samples to enable both basic research as well as the development of effective treatments and cures. Currently under review by the National Institute of Aging (NIA), the goal of this administrative supplement grant submission is to address the current gaps in AD/ADRD research by developing the Brain and Other Tissues for AD/ADRD Research Resource (BOTARR) to provide an all-encompassing biospecimen and donor data collection model for the AD research community.
HTORR-NIAID high priority HIV human biospecimen recovery program grant submission
Under review by National Institute of Allergy and Infectious Diseases (NIAID), the goal of this administrative supplement grant submission is obtain funding for PY4 to continue the HTORR-NIAID High Priority HIV Human Biospecimen Recovery Program. This program was developed and successfully implemented for three program years to support a large-scale biospecimen collection program (~120 aliquots per donor) from HIV+ donors, using multiple preservation formats to support the advancement of sequencing studies in Dr. H. Clifford Lane’s laboratory at NIAID.
Our recently completed supplemental awards:
Alzheimer’s Disease Biospecimen Resource (ADBR) Program
The HTORR-ADBR Program administrative supplemental grant was funded by the National Institute on Aging (NIA) to support Alzheimer’s Disease and AD-related dementia (AD/ADRD). The goal of the ADBR was to serve as a comprehensive resource that provides biospecimens from all body systems, including whole brains or hemispheres, from AD and normal donors to address a diverse range of investigator-driven experimental needs for the AD research community.
Autism Spectrum Disorder (ASD) Brain Recovery Program
The HTORR-ASD Brain recovery Program was supported by the National Institutes of Mental Health NIMH) to advance ASD research. The major goals of this program were to support NIH’s NeuroBioBank program by developing and maintaining a recovery network to screen and collect biospecimens from ASD and normal donors for the NeuroBioBank at University of Maryland. Doing so provided investigators with expanded access to valuable donated human brain biospecimens to support the advancement of their ASD studies.
Diversity Supplement Program
The Diversity Supplements Program was established by the NIH to provide support for individuals from diverse backgrounds looking to develop their careers in research. One component of this HTORR administrative supplement award was a research project that evaluated the integrity and viability of long term stored human tissue samples utilizing NDRI’s collection of Lymphangioleiomyomatosis (LAM) samples, as well as to evaluating LAM investigator interest in utilizing long term stored human tissues samples.
Ocular Procurement for Alzheimer’s Disease (OTRAD) Program
NDRI was awarded a research resource grant from the National Institute on Aging (NIA) to support the development of the Ocular Tissue Resource for Alzheimer’s Disease (OTR-AD). The overall objective of the OTR-AD was to provide well-annotated ocular and other supporting tissues/fluids from defined cohorts of healthy and AD donors to meet the emerging experimental needs of AD investigators.
Alterations & Renovations Program:
The Alterations & Renovations (A&R) Program was funded by Office of Research Infrastructure Programs/ Division of Comparative Medicine (ORIP/DCM), provides the opportunity to improve and expand the cold storage infrastructure of HTORR by obtaining new equipment for the biorepository and Tissue Source Sites (TSS).